Anti-Fertility Effect of Allethrin Based Liquid Electric Repellent on the Testes and Epididymis of Adult Male Sprague-Dawley Rat

Abstract

The incidence of male infertility in a population has important demographic and health implications. Effect of Allethrin on the testes and epididymis is being investigated. The aim of this research work is to determine the effect of allethrin on male reproductive system (testes and epididymis). A total number of twenty (20) adult male Sprague-Dawley rats of mean weight 160g were divided into four groups. Group 1, 2 and 3 animals were daily exposed to electric mortein insecticides for 30 minutes, 1 hour and 1 hour 30minutes respectively for 30 days. Group 4 rats were designated as the Control group. The exposed animals experienced reduction in body weight, significant decrease in numbers of neutrophils, significant increase in white blood cell count and packed cell volume. Andrological parameters showed significant decrease in sperm count, sperm motility, percentage of normal sperm cells and serum testosterone level when compare with the control. Histo-architecture of the testes and epididymis showed seminiferous tubules with incomplete maturation of germinal cell layers with no spermatozoa in their lumen and some epididymal cells were also devoid of sperms. Control rats’ testes and epididymis histological parameters appeared normal. Continuous exposure to inhalation of allethrin causes reduction in body weights. Moreover, this study has revealed its anti-fertility effect on the male reproductive system.