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Physicochemical quality, microbial load and health risk assessment of groundwater in view of the sustainable development goals 3, 6, and 11 in Osogbo, Nigeria
(2024) Towolawi, Adeleke Taofik; Adegbore, Abidemi Kafayat; Badmus-Oladapo, Ramot Bolanle; Adegbite, Kabirat Iyabode; Oladeji, Francis Olusegun; Abdulsalami, Baseerat Adebola; Adeoye, Moriam Dasola
Water is abundantly available, but that of good quality for good health and well-being is not accessible thereby making cities and communities to be doubted for sustainability. Ascertaining water of good quality requires more than comparing the laboratory results with regulatory standards; exploring the multifaceted approach to check the quality of water is highly imperative and mundane to achieving the related SDGs 3, 6, and 11 to this study. The Osun Water Corporation Laboratory analysed physicochemical parameters, heavy/ toxic metals, and microbial loads of ten households’ water samples across Osogbo and environs, Osun State, Nigeria. The obtained data were descriptively compared with four drinking water standards, recent works (2018-2024), and further subjected to health risk assessments (CDI, CDIing, CDIderm, HQ, HI, and PLCR) using SPSS v23. The results indicated that the consumers were not free from microbial loads (total plate count, total coliform, and Escherichia coli in 100 % locations), cyanide (in 60 % locations), K (in 90 % locations), Cr (in 60 % locations), Cd (in 100 % locations), Mo (in 80 % locations), N-nitrate, and Free CO2 contamination as their levels were higher than the limits of WHO, UNICEF (2014), and NIS 554 (2015) while HCO3- was higher that the WHO (2008) limit. The average CDIing values ranged from 3.77E-2 at location C to 8.54E-3 at location H for children and from 1.32E-1 at location C to 3.00E-2 at location H for adults. The average CDIderm values ranged from 2.48E-4 at location C to 5.64E-5 at location H for children and from 4.61E-4 at location C to 1.05E-2 at location H for adults. The HQing of Cd, Cr, and Cu were > 1, while the HQderm of Cd was > 1, thereby indicating a low non-carcinogenic risk. The adults’ HIing was higher than that of the children except at locations DEC. The PLCRing for adults > PLCRing for children > PLCRderm for adults > PLCRderm for children. The study concluded that the health implications of the limit-exceeded parameters determined noncompliance with SDGs 3, 6, and 11. The children were more prone to ingestion and dermally-contact side effects than the adults. The HQing is generally > HQderm. There is a need for a joint effort to make potable water available for the residents of Osogbo and its environs.
Trends and patterns of online newspapers in Nigeria: A study of Sahara reporters and the Premium time
(2021) Sanni, Azeez Olusegun
The drift of readers, viewers and advertisers from newspapers and broadcast stations to online news publications is not only limited to the developed world but has also become a visible trend in the developing countries such as Nigeria. Since Professor Marsha MacLuah opined in 1987 that the world would become a hamlet of communication, online publication has truly made the world a global village by providing easy access to the media contents which the readers at their convenient times and places can read as the news breaks. This study examines trends and patterns of online publications in Nigeria. This study is anchored on two theories: the technological determinism theory and the media morphosis theory of mass communication. It employs content analysis as its design so as to know what constitutes the trend and pattern of online newspapers in Nigeria, in this case, Sahara Reporters and Premium Times. After the analysis of trends of the two selected online news media shows that the selected media, it was discovered that they have a penchant for deep investigative stories and multimedia presentation with hyperlinks that make it easy for readers to navigate to other sections of the stories. It was also discovered that the two online newspapers usually link their stories to video clips which the readers could watch with their mobile devices. This can be concluded to be one of the major innovations that drive online newspapers, which has also increased the adoption of the news platforms by online audiences. It was recommended that media owners should not allow the commercial interest to derail them from the media social responsibility expected of it in the society by using latest technology to make access to information easy for their readers.
In-Silico Investigation on Chloroquine Derivatives: A Potential Anti-COVID-19 Main Protease
(2022) Adeoye, Moriam Dasola
SARS-CoV-2 (Covid 19) continues to be a great threat to lives globally as it causes illnesses such as the common cold, severe acute respiratory syndrome and spreads easily among people. In this work, thirteen molecular compounds were studied via quantum chemical calculations, molecular docking, and dynamic simulation, and ADMET (absorption, distribution, metabolism, excretion, and toxicity). The obtained descriptors (Log P, HBA, HBD, and molecular weight) showed that the studied compounds have the ability to act as a drug. Thus, it was detected that all the studied selected compounds possess a better tendency to inhibit main coronavirus protease; however, compound C1 has a higher tendency to inhibit main coronavirus protease than the other compounds, including the standard (Chloroquine). ADMET properties of compound C1 proved that the predicted ADMET level was better than the ADMET properties of the referenced drug.
Social media coverage of climate change in post covid era (2020-2023): A study of X
(2024) Sanni, Azeez Olusegun
The phenomenon of climate change is fast gaining attention among the peoples of the world, especially now that Covid-19 has been described by World Health Organisation as having no threat. Several nations and governments are taking actions and making plans to mitigate the effects of this phenomenon or see how they can circumvent the various ways climate change affects their people, particularly that the deadline of Sustainable Development Goals target draws near in 2030 and having environment at the heart of Goal 15. At different times, there had been discussions at governmental, organizational and group levels. At the individual level, the discussion is also common even among people with little or no familiarity, particularly on the social media. This study sought to know how Twitter, now X, a major social networking site, has been advancing the climate change discussion. A content analysis of trends of discussion on topics bordering on climate change on X was undertaken to examine how trendy these topics are. The period of January to June 2022 was chosen as the duration. It was found that X was used very heavily to spread information about climate change and that majority of the tweets centred on its effects on people around the world.
Theoretical Evaluation of Potential Anti-Alanine Dehydrogenase Activities of Acetamide Derivatives
(2022) Adeoye, Moriam Dasola
Tuberculosis is an airborne communicable syndrome, which has been observed to be among the top ten (10) causes of death worldwide. This work studied eleven molecular compounds via quantum chemical calculations, molecular docking method, and ADMET (absorption, distribution, metabolism, excretion, and toxicity). The selected obtained descriptors (Log P, HBA, HBD, and molecular weight) showed that the studied compounds have the ability to act drug-like. Compound D inhibited far better than the other studied ligands as well as the standard. ADMET properties of compound D proved that the predicted ADMET level was closer to the ADMET properties of the referenced drug (Isoniazid).