Roles of Quercetin and Omeprazole in Ovotoxicity Induced by Indomethacin in Wistar Rats

Abstract

Background: Quercetin, a flavonoid in fruits and vegetables, offers health benefits like anti carcinogenic, anti-inflammatory, and antioxidant effects. This work investigated role of quercetin against indomethacin-induced histological and functional changes in the ovaries of female Wistar rats. Methods: 25 adult female Wistar rats with an average weight of 150 g ( ± 10 g) were used in the experiment, they were randomly assigned into 5 groups. All animals except those in control group (group A) were given a single oral dose of 30 mg/kg of indomethacin. Group B - induced with (30mg/ kg) indomethacin only, in addition group C, D, E received, omeprazole, quercetin (50mg/kg), omepra zole (20mg/kg) and quercetin (50mg/kg) respectively. All administration were done orally for 30days. Results: Reduced FSH serum levels were observed in the indomethacin and omeprazole treated group compared to other groups. There was a reduction of LH serum in the indomethacin and omeprazole treated group compared to the control group. Serum lipid peroxidase level concentration was significantly elevated in the indomethacin only treated group compared to the control and all other treated groups. Histological evaluation revealed pathological changes in the indomethacin only treated group. Conclusions: Indomethacin negatively impacts ovarian function while quercetin confers a protec tive role. The triple combination of indomethacin, omeprazole, and quercetin shows observable posi tive effect of quercetin against indomethacin-induced ovotoxicity